Cortexyme Announces Pipeline Update and Anticipated 2021 Milestones
— Based upon successful completion of the GAIN Trial’s interim analysis, pipeline expansion announced for 2021
— Atuzaginstat to be studied in the PEAK trial, a new Phase 2 study for Parkinson’s disease
— COR588, a novel lysine gingipain inhibitor, on track to enter the clinic in Q3 2021
— Top-line data in 643 subject Alzheimer’s disease pivotal GAIN Trial on schedule to be announced in Q4 2021
— Top-line data in 233 subject periodontal disease clinical study to be announced in Q4 2021
— Current cash position projected to fund operations into 2023
— GAIN open-label extension (OLE) rollover to date has been approximately 90% of eligible participants
“2020 was a year of numerous corporate and clinical accomplishments. We exceeded our enrollment target in the pivotal GAIN Trial for Alzheimer’s disease on schedule and completed a successful interim analysis in
Anticipated Key Milestones for 2021
Atuzaginstat in Mild to Moderate Alzheimer’s Disease (AD)
- The pivotal GAIN Trial’s final top-line data read out for atuzaginstat in patients with mild to moderate Alzheimer’s disease is planned in Q4 2021.
Enrollment into the
U.S.GAIN Trial OLE is robust despite the ongoing global pandemic, with approximately 90% of eligible subjects in the United Statescontinuing in the open label portion of the study. Completion of enrollment in the GAIN OLE is expected in Q4 2021.
Atuzaginstat in Periodontal Disease (PiD)
- GAIN Trial top-line data for atuzaginstat in periodontal disease is planned in Q4 2021. The GAIN Trial includes a periodontal substudy of 233 subjects with efficacy data on typical regulatory endpoints of pocket depth and clinical attachment level at 6 months and 1 year.
Atuzaginstat in Parkinson’s Disease (PD)
- The placebo controlled, multicenter Phase 2 study of atuzaginstat in patients with Parkinson’s disease, the PEAK Trial (Parkinson’s gingipain inhibitor Trial), has begun study start-up activities. The first patient in is expected in Q3 2021.
COR588 IND-enabling studies are proceeding according to expectations and a first-in-human study is expected to begin in Q3 2021. COR588 is a unique small molecule lysine gingipain inhibitor with once daily oral dosing that
Cortexymeintends to position in periodontal disease and other new indications.
- Two arginine gingipain inhibitors, COR788 and COR822, have been selected as lead compounds to progress toward IND-enabling studies, including manufacturing scale-up and dose range-finding toxicology studies based on their properties of potency, selectivity, pharmacologic efficacy, and pharmacokinetics. Arginine gingipain is a distinct target associated with P. gingivalis that contributes to bacterial survival, replication and toxicity. An arginine gingipain inhibitor may be used as monotherapy in new indications or potentially additively with lysine gingipain inhibitors, like atuzaginstat. Both molecules have novel composition of matter (patent pending), are brain penetrant and orally available.
- Announcements of new original research including potential clinical studies in additional indications are expected during 2021.
Cash Position and Financial Update
Statements in this press release contain “forward-looking statements” that are subject to substantial risks and uncertainties. Forward-looking statements contained in this press release may be identified by the use of words such as “anticipate,” “expect,” “believe,” “will,” “may,” “should,” “estimate,” “project,” “outlook,” “forecast” or other similar words. Examples of forward-looking statements include, among others, statements we make regarding our business plans, strategy, timeline, prospects and milestone expectations; the timing and success of our clinical trials and related data, including with respect to the GAIN and PEAK trials; the potential of atuzaginstat to treat Alzheimer’s disease, periodontal disease, Parkinson’s disease and other potential indications; our ability to fund planned operating and capital expenditures; the timing of announcements and updates relating to our clinical trials and related data; the timing of and our ability to enroll patients into our clinical trials; the potential therapeutic benefits, safety and efficacy of our product candidate or library of compounds; statements about our ability to obtain, and the timing relating to, regulatory submissions and approvals with respect to our drug product candidate; and expected cash runway and financial update. Forward-looking statements are based on Cortexyme’s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict and could cause actual results to differ materially from what we expect. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, but are not limited to, the risks and uncertainties described in the section titled “Risk Factors” in our Annual Report on Form 10-K filed with the
Chief Financial Officer