Cortexyme to Present at National Academies Forum on Tuesday, June 11, 2019
-- Event will be webcast, with
In her remarks, Ms. Lynch will review the scientific rationale and data supporting a key role for Porphyromonas gingivalis in the development of Alzheimer’s disease, based on the identification of the bacteria in the brain of Alzheimer’s patients and its ability to cause neurodegeneration, inflammation, and other pathology associated with Alzheimer’s in animal models. Preclinical and clinical evidence indicates that treatment with Cortexyme’s investigational gingipain inhibitor, COR388, may be beneficial in slowing or stopping disease progression. In addition to reviewing the company’s foundational publication in Science Advances earlier this year, Ms. Lynch will highlight the design of the Phase 2/3 GAIN trial, Cortexyme’s large, international clinical study of COR388 in subjects with mild to moderate Alzheimer’s disease.
“The National Academies’ Forum on Microbial Threats has assembled a deep roster of government, academic, private sector, and non-profit speakers to explore how the distinction between infectious and noncommunicable diseases is breaking down, and what that means for human health,” said Lynch. “Cortexyme appreciates the opportunity to contribute to the conversation by sharing what we’ve learned from our research into the bacterial hypothesis for the development of Alzheimer’s, including the clinical experience with COR388.”
The event will be webcast, with a live broadcast and archive of
individual presentations both expected to be available here.
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uncertainties described in the section titled “Risk Factors” in the
final prospectus related to Cortexyme’s initial public offering filed
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