Washington, D.C. 20549


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the Securities Exchange Act of 1934 (Amendment No.     )

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Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting of   CORTEXYME, INC.   To Be Held On:   June 8, 2020, at 11:00 A.M. local time   via live webcast at      COMPANY NUMBER         ACCOUNT NUMBER         CONTROL NUMBER           This communication presents only an overview of the more complete proxy materials that are available to you on the Internet.  We encourage you to access and review all of the important information contained in the proxy materials before voting.   If you want to receive a paper or e-mail copy of the proxy materials you must request one. There is no charge to you for  requesting a copy. To facilitate timely delivery please make the request as instructed below before 5/29/20.   Please visit, where the following materials are available for view:      • Notice of Annual Meeting of Stockholders      • Proxy Statement      • Form of Electronic Proxy Card      • Annual Report on Form 10-K   TO REQUEST MATERIAL:   TELEPHONE: 888-Proxy-NA (888-776-9962) 718-921-8562 (for international callers)      E-MAIL:      WEBSITE:   TO VOTE:      ONLINE: To access your online proxy card, please visit and follow the  on-screen instructions or scan the QR code with your smartphone. You may enter your voting  instructions at up until 11:59 PM Eastern Time the day before the cut-off  or meeting date.      VIRTUALLY AT THE MEETING: Access “” password:  cortexyme2020 (case sensitive) and follow the on screen instructions. Have your notice  available when you access the web page, and use the Company Number and Account  Number shown above.      TELEPHONE: To vote by telephone, please visit to view the materials  and to obtain the toll free number to call.      MAIL: You may request a card by following the instructions above.        1. To elect two Class I directors to hold office until the 2023  annual meeting of stockholders or until their respective  successors are elected and qualified:   2. To ratify the appointment of BDO USA, LLP as the  independent registered public accounting firm of the  Company for its fiscal year ending December 31, 2020.         NOMINEES:      Margaret A. McLoughlin, Ph.D.      Una Ryan, OBE, Ph.D.         Note: The proxies are authorized to vote in their discretion upon  such other business as may properly come before the Annual  Meeting or any adjournment or postponement thereof.            Our Board of Directors recommends that you vote FOR the  election of the director nominees named in Proposal One of  the Proxy Statement and FOR the ratification of the appointment  of BDO USA, LLP as our independent registered public  accounting firm as described in Proposal Two of the Proxy  Statement.                           Please note that you cannot use this notice to vote by mail.